Contributions of some biological activities of honey bee venom

Written by
Journal of Apicultural Research

Vol. 53 (4) pp. 441-451
DOI

10.3896/IBRA.1.53.4.13
Date

September 2014
Article Title

Contributions of some biological activities of honey bee venom
Author(s)

Enas M Ali
Abstract

Candida albicans is generally one of the most commonly isolated fungal pathogens from the human body. Bee venom (BV) is a natural substance, reported to have antimicrobial activity and to boost the immune system. This study aimed to evaluate the effect of bee venom as antimycotic agent, and to assess its antidimorphic effect in comparison with some antimycotic drugs, and also, the antitumour activity of BV was studied. It was revealed that BV was the most potent antimycotic agent, with minimum inhibitory concentration (MIC) of 40 μg ml-1 whereas, flucytosine was relatively weak with MIC of 320 μg ml-1. The tested antifungal drugs block dimorphism at a concentration significantly lower than their MIC values. An in vivo study using Swiss albino mice clearly indicated that in candidiasis induced mice, treated with BV, no fungal load was evident in kidney, liver or spleen tissues. Mammary carcinoma bearing mice treated with BV indicated that the tumour was suppressed in a dose dependent manner, and that the survival of mice treated with BV was prolonged as compared to the BV untreated controls. In conclusion, the results suggest that bee venom could be developed as a natural antimycotic drug. More attention should be paid to natural inhibitors of tumour growth such as BV and other venoms and screening their biological activities.
Keywords

honey bee venom, C. albicans, antimycotics, antidimorphic activity, antitumour, candidiasis
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